Session Detail

"Pain" is an unpleasant experience that most people have had and it is a common or major symptom of many diseases. In order to ensure the effectiveness of the treatment of pain and process possible adverse reactions, pain assessments are necessary for patients. In clinical situations, self-reported questionnaires are mostly used for pain assessments. These scales aren’t able to reflect the pain in real time, and understaffing is a load on the medical staff, leading to pain monitoring being difficult to achieve. According to previous research, the physiological parameters of heart rate variability (HRV) and photoplethysmography (PPG) change during the pain production process, and a model established by the binary logistic regression analysis is suitable for discriminating pain. This study used a binary logistic regression model to discriminate pain, and the accuracy of the discriminations was 80%. In the future, this model will be used to establish a monitoring system for immediate monitoring, and assist medical staff to make better assessments to achieve effective pain monitoring and management.

 

Continuing the laboratory's many years of experience, the atmospheric low-temperature plasma system has been developed, and its functionality has been proven based on laboratory research. Therefore, this study turned this functional equipment into commercialization. Combine the plasma system in a handheld device. The device is divided into two main parts: the excitation position of plasma and the grip position. It's easy to use and has a graceful outline. Its internal structure contains plasma generator and lines for connecting Helium gas cylinder. Designing a circular air diffuser around the surface of excited plasma, in addition to increasing the uniformity of the excitation surface and decreasing the excitation temperature of plasma. The electrode is wrapped in the grip to ensure its safe to use. Considering about its appearance, structural design, and product process and design principles of the mold. We completed the structure, shaped design and printed a 3D model at the current stage. Integrate all functional components and test the finished product, like the excitation temperature, excitation species and excited electronic patterns, etc. The excitation temperature of plasma is maintained below 34 ̊C for 600 seconds. Using optical emission spectrometry to detect OH and singlet oxygen. The plasma operating frequency is 1.312 kHz, power supply is 32.2 kV, working current is 66.4 mA, and power consumption is 0.66 W. The above data results are not different from the previous laboratory plasma system. In conclusion, this product can be used on improving wound healing, shortening the time of wound healing and sterilizing wounds in the future. Species produced by plasma can induce fibroblasts to accelerate proliferation and their ability to crawl during wound healing. Evaluate the efficiency of sterilization on E. coli by plasma system. The degree of sterilization can reach D-value after 300 seconds plasma treatment. The temperature is also suitable for the treatment of human skin.

 

Ultrasound is being used frequently in breast imaging, where it plays many important roles in both symptomatic breast imaging and breast screening, for example distinguishing benign lesions from malignant lesions and guidance of interventional procedures. There is an increasing need for the ultrasound operator to be appropriately trained and skilled. This may be overcome with the use of anthropomorphic training phantoms. Therefore, the purpose of this study is to develop a low cost and easy to fabricate gelatin based biopsy training phantom for all types of breast needle biopsy which requires precise insertion. Developed gelatin based phantom is embedded with a simulated malignant tumor, benign tumors, and a cyst. This proposed phantom can be easily fabricated by trainee himself for breast biopsy training. Young’s modulus and acoustic properties (speed of sound, attenuation coefficient, and backscattering) for the gelatin tissue phantom and simulated tumors are studied. The efficiency of the developed phantom in improving biopsy skill level of residents was evaluated. It was found that the residents’ subjective confidence levels for performing challenging ultrasound-guided breast biopsy procedures substantially increased with the use of phantom simulation training. Therefore, our phantom is realistic enough such that the training outcome can be linked to the performance of the residents when they perform a biopsy on patients.

 

Since the technological advancements and civilization development, numerous medical supplies are being developed, manufactured and consumed. Medical supplies will come in contact with wounds or tissues directly. If the sterilization procedures were not followed properly and performed correctly, it could lead to microbial contaminations and en-danger the lives of patients. However, atmospheric cold plasma has excellent sterilization performance. Our research utilizes magnetron along with our custom wave guide and design to develop a microwave cold plasma sterilization equipment. Equipment stability will be tested as well as the sterilization effectiveness under different plasma exposure time and different gas molecules against E. Coli. The results showed that under the pressure of 5×10-2 torr, 99.99% sterilization of E. Coli were obtained after 15-second exposure and 30-second exposure for every test group. In the meantime we proved that simply changing any one of the parameters such as pressure, microwave irradiation and the maximum temperature of the test piece not more than 65°C, the sterilization effect was not effective. All kinds of species in the plasma can be effectively sterilized. Final result showed our research of self-made microwave cold plasma sterilization equipment can sterilize E. coli quickly while producing uniform and steady plasma.

 

The aim of this study was to investigate the SpO2 features during rapid eye movement phase (REM) of the patients with chronic obstructive pulmonary disease (COPD). Ten COPD patients (mean age 75.7± 7.5 years) were recruited from outpa-tient clinics of Chang Gung Memorial Hospital under inform consent. Overnight polysomnographic (PSG) data was record-ed from the polysomnography system and channel setup was according to the 2007 recommendations from the American Academy of Sleep Medicine (AASM). After data processing, lower proportion of REM was noted comparing to previous data from non-COPD elderly (6.9% vs. 12.6% of total sleep time in the previous data). The variation of SpO2 during REM was 2%, while 0.4% when sleep onset. In addition, the patients with the higher hypoxia index had lower SpO2 levels and larg-er SpO2 variation. In summary, the COPD patients would have SpO2 drops with a certain level of variation when REM. The potential application of SpO2 feature during sleep could be helpful for identifying the REM phase of the COPD in our automated REM detection algorithm.