Session Detail

The present study was employed 3D printing technology to create a porous scaffold contained with strontium (Sr)-doped calcium silicate (CS) and polycaprolactone (PCL) for guiding tissue regeneration (GTR). Physico-chemical characterization of the scaffolds was identified by optical and scanning electron microscopy, X-ray diffractometer and universal testing ma-chine. As the results, it can be seen that the compressive strength of the scaffold was about 6.2 MPa. After soaking for 3 days in simulated body fluids, the sample was covered with a dense layer of bone-like apatite. The results indicate the Sr-doped CS/PCL composite exhibited a favorable bioactivity and osteoconductive properties that could be served as a promising biomaterial for treatment of dental osteopenia patients.

 

The dynamic role of photosensitizer (PS) concentration under various light intensity is measured. The efficacy of photodynamic therapy (PDT) and cell viability (CV) are measured (in vitro) and analyzed by analytic and numerical modeling. for a fixed PS concentration, CV is a nonlinear deceasing function of light intensity and exposure time; for a fixed light intensity, higher PS concentration achieves higher efficacy (except the transient stage), or smaller CV (at steady-state), in consistent to our analytic formulas. Finally, anti-cancer efficacy may be enhanced by the resupply of PS and/or external oxygen.

 

Collagen is an abundant structural protein in all animals. However, how collagen structurally organized into the functional tissue is still an open question. Here, using the chicken as an experimental system in conjunction with Fast Fourier Transform second harmonic generation microscopy, we investigate the corneal structural variation at different stage of developing embryos. The results indicate both the thickness and collagen alignment of corneal stroma continue involving with developing process of cornea but their event curves are different at their time stage.

 

Air pollution and nanoparticles are emerging as the most dangerous pollutants for our health effects going far beyond the simple toxicity to the lung. However, there are no effective in vitro models to test what will happen if particulates in human lung, we also test them in dish or animal test. In recent years, organs on chips are new technology that are microfluidic cell culture devices with separate parenchymal and vascular compartments lined by living human cells that mimic the multicellular architecture, tissue-tissue interfaces and relevant physical microenvironment of key functional units of living organs, while providing dynamic vascular perfusion in vitro. So we want to create a microfluidic lung-on-a-chip lined by human primary alveolar epithelium interfaced with endothelium and imitate environment in human body. Now, our present results demonstrated we have successfully cultured cell on the chip for long-term. At the same time, the function of the cell-cell interaction is verified, and the single-layer cells are stimulated by the particles to investigate the toxicity analysis. Finally, we hope that the system can bring different test results to the increasingly serious air pollution problem, and bring more applications and development possibilities to organs on chip.